CRISPR causes significantly greater DNA damage than previously thought, study finds - PBS NewsHour

The DNA damage found in the new study included deletions of thousands of DNA bases, including at spots far from the edit. Some of the deletions can silence genes that should be active and activate genes that should be silent, including cancer-causing genes. ....
https://www.pbs.org/newshour/health/crispr-causes-significantly-greater-dna-damage-than-previously-thought-study-finds